Veterinary Pathobiology
Texas A&M University Veterinary Medicine
& Biomedical Sciences
Texas A&M University
Veterinary Pathobiology
Christopher Seabury

Christopher Seabury

Professor Department of Veterinary Pathobiology
Contact
Genome Lab
CSeabury@cvm.tamu.edu
9798452720
TAMU Mailstop: 4467

Research and Scholarly Interests

Mammalian molecular genetics, genomics, and population genetics; animal disease genomics; utilization of population and quantitative genetics to elucidate host loci and relevant variation influencing differential susceptibility to disease, adaptability, and feed efficiency; next generation sequencing and de novo genome assembly as a mechanism to enable novel research programs in non-model mammalian and avian species of interest.

EDUCATION

  • B.S., Sul Ross State University, 1997
  • M.S., Sul Ross State University, 2000
  • Ph.D., Texas A&M University, 2004
  • Genomics
  • Genetics
  • Infectious Disease
  • Christopher M Seabury, David L Oldeschulte, Mahdi Saatchi, Jonathan E Beever, Jared E Decker, Yvette A Halley, Eric K Bhattarai, Maral Molaei, Harvey C Freetly, Stephanie L Hansen, Helen Yampara-Iquise, Kristen A Johnson, Monty S Kerley, JaeWoo Kim, Daniel D Loy, Elisa Marques, Holly L Neibergs, Robert D Schnabel, Daniel W Shike, Matthew L Spangler, Robert L Weaber, Dorian J Garrick, Jeremy F Taylor (2017). Genome-wide association study for feed efficiency and growth traits in U.S. beef cattle. BMC GENOMICS. 1, 386
  • Decker JE, McKay SD, Rolf MM, Kim J, Molina Alcalá A, Sonstegard TS, Hanotte O, Götherström A, Seabury CM, Praharani L, Babar ME, Correia de Almeida Regitano L, Yildiz MA, Heaton MP, Liu WS, Lei CZ, Reecy JM, Saif-Ur-Rehman M, Schnabel RD, Taylor JF (2014). Worldwide patterns of ancestry, divergence, and admixture in domesticated cattle. PLOS GENET. 3,
  • Halley YA, Dowd SE, Decker JE, Seabury PM, Bhattarai E, Johnson CD, Rollins D, Tizard IR, Brightsmith DJ, Peterson MJ, Taylor JF, Seabury CM (2014). A draft de novo genome assembly for the northern bobwhite (Colinus virginianus) reveals evidence for a rapid decline in effective population size beginning in the Late Pleistocene. PLOS ONE. 3,
  • Pinedo PJ, Galvão KN, Seabury CM (2013). Innate immune gene variation and differential susceptibility to uterine diseases in Holstein cows. THERIOGENOLOGY. 4, 384-90
  • *Holly L. Neibergs, *Christopher M. Seabury, Andrzej J. Wojtowicz, Zeping Wang,Erik Scraggs, Jennifer Kiser, Mahesh Neupane, James E. Womack, Alison Van Eenennaam, G. Robert Hagevoort, Terry W. Lehenbauer, Sharif Aly, Jessica Davis, Jeremy F. Taylor (2014). Susceptibility Loci Revealed for Bovine Respiratory Disease Complex in Pre-Weaned Holstein Calves BMC GENOMICS .
  • Mahdi Saatchi, Jonathan E Beever, Jared E. Decker, Dan B. Faulkner, Harvey C Freetly, Stephanie L Hansen, Helen Yampara-Iquise, Kristen A Johnson, Stephen D Kachman, Monty S Kerley, JaeWoo Kim, Daniel D Loy, Elisa Marques, Holly L Neibergs, E John Pollak, Robert D Schnabel, Christopher M Seabury, Daniel W Shike, Warren M Snelling, Matthew L Spangler, Robert L Weaber, Dorian J Garrick, and Jeremy F Taylor (2014). QTLs associated with dry matter intake, metabolic mid-test weight, growth or feed efficiency have little overlap across 4 beef cattle studies BMC GENOMICS.
  • Christopher M Seabury, James E Womack, Jorge Piedrahita, James N Derr (2004). Comparative PRNP genotyping of U.S. cattle sires for potential association with BSE. MAMMALIAN GENOME : OFFICIAL JOURNAL OF THE INTERNATIONAL MAMMALIAN GENOME SOCIETY. 10, 828-33
  • Christopher M Seabury, Rodney L Honeycutt, Alejandro P Rooney, Natalie D Halbert, James N Derr (2004). Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 42, 15142-7
  • C M Seabury, J N Derr (2004). Identification of a novel ovine PrP polymorphism and scrapie-resistant genotypes for St. Croix White and a related composite breed. CYTOGENETIC AND GENOME RESEARCH. 1-4, 85-8
  • Alison Van Eenennaam, Holly Neibergs, Christopher Seabury, Jeremy Taylor, Zeping Wang, Erik Scraggs, Robert D Schnabel, Jared Decker, Andrzej Wojtowicz, Sharif Aly, Jessica Davis, Patricia Blanchard, Beate Crossley, Paul Rossitto, Terry Lehenbauer, Robert Hagevoort, Erik Chavez, J Shannon Neibergs, James E Womack (2014). Results of the BRD CAP project: progress toward identifying genetic markers associated with BRD susceptibility. ANIMAL HEALTH RESEARCH REVIEWS. 2, 157-60
  • Christopher M Seabury, Clare A Gill, Joe W Templeton, Joseph B Dyar, James N Derr, David L Adelson, Elaine Owens, Donald S Davis, Duane C Kraemer, James E Womack (2007). Molecular characterization of the Rocky Mountain elk (Cervus elaphus nelsoni) PRNP putative promoter. THE JOURNAL OF HEREDITY. 7, 678-86
  • C M Seabury, E J Cargill, J E Womack (2007). Sequence variability and protein domain architectures for bovine Toll-like receptors 1, 5, and 10. GENOMICS. 4, 502-15
  • Melissa M Kahl-McDonagh, Philip H Elzer, Sue D Hagius, Joel V Walker, Quinesha L Perry, Christopher M Seabury, Andreas B den Hartigh, Renee M Tsolis, L Garry Adams, Donald S Davis, Thomas A Ficht (2006). Evaluation of novel Brucella melitensis unmarked deletion mutants for safety and efficacy in the goat model of brucellosis. VACCINE. 24, 5169-77
  • C M Seabury, N D Halbert, P J P Gogan, J W Templeton, J N Derr (2005). Bison PRNP genotyping and potential association with Brucella spp. seroprevalence. ANIMAL GENETICS. 2, 104-10
  • Jared E Decker, Stephanie D McKay, Megan M Rolf, Jaewoo Kim, Antonio Molina Alcalá, Tad S Sonstegard, Olivier Hanotte, Anders Götherström, Christopher M Seabury, Lisa Praharani, Masroor Ellahi Babar, Luciana Correia de Almeida Regitano, Mehmet Ali Yildiz, Michael P Heaton, Wan-Sheng Liu, Chu-Zhao Lei, James M Reecy, Muhammad Saif-Ur-Rehman, Robert D Schnabel, Jeremy F Taylor (2014). Worldwide patterns of ancestry, divergence, and admixture in domesticated cattle. PLOS GENETICS. 3,
  • Yvette A Halley, Scot E Dowd, Jared E Decker, Paul M Seabury, Eric Bhattarai, Charles D Johnson, Dale Rollins, Ian R Tizard, Donald J Brightsmith, Markus J Peterson, Jeremy F Taylor, Christopher M Seabury (2014). A draft de novo genome assembly for the northern bobwhite (Colinus virginianus) reveals evidence for a rapid decline in effective population size beginning in the Late Pleistocene. PLOS ONE. 3,
  • P J Pinedo, K N Galvão, C M Seabury (2013). Innate immune gene variation and differential susceptibility to uterine diseases in Holstein cows. THERIOGENOLOGY. 4, 384-90
  • Christopher M Seabury, Scot E Dowd, Paul M Seabury, Terje Raudsepp, Donald J Brightsmith, Poul Liboriussen, Yvette Halley, Colleen A Fisher, Elaine Owens, Ganesh Viswanathan, Ian R Tizard (2013). A multi-platform draft de novo genome assembly and comparative analysis for the Scarlet Macaw (Ara macao). PLOS ONE. 5,
  • Colleen A Fisher, Eric K Bhattarai, Jason B Osterstock, Scot E Dowd, Paul M Seabury, Meenu Vikram, Robert H Whitlock, Ynte H Schukken, Robert D Schnabel, Jeremy F Taylor, James E Womack, Christopher M Seabury (2011). Evolution of the bovine TLR gene family and member associations with Mycobacterium avium subspecies paratuberculosis infection. PLOS ONE. 11,
  • Amelia A Romoser, Patricia L Chen, J Michael Berg, Christopher Seabury, Ivan Ivanov, Michael F Criscitiello, Christie M Sayes (2011). Quantum dots trigger immunomodulation of the NFκB pathway in human skin cells. MOLECULAR IMMUNOLOGY. 12-13, 1349-59
  • Christopher M Seabury, Eric K Bhattarai, Jeremy F Taylor, Ganesh G Viswanathan, Susan M Cooper, Donald S Davis, Scot E Dowd, Mitch L Lockwood, Paul M Seabury (2011). Genome-wide polymorphism and comparative analyses in the white-tailed deer (Odocoileus virginianus): a model for conservation genomics. PLOS ONE. 1,
  • J B Osterstock, S Sinha, C M Seabury, N D Cohen (2010). Effect of classifying disease states in genetic association studies for paratuberculosis. PREVENTIVE VETERINARY MEDICINE. 1-2, 41-9
  • Christopher M Seabury, Paul M Seabury, Jared E Decker, Robert D Schnabel, Jeremy F Taylor, James E Womack (2010). Diversity and evolution of 11 innate immune genes in Bos taurus taurus and Bos taurus indicus cattle. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1, 151-6
  • Jared E Decker, J Chris Pires, Gavin C Conant, Stephanie D McKay, Michael P Heaton, Kefei Chen, Alan Cooper, Johanna Vilkki, Christopher M Seabury, Alexandre R Caetano, Gary S Johnson, Rick A Brenneman, Olivier Hanotte, Lori S Eggert, Pamela Wiener, Jong-Joo Kim, Kwan Suk Kim, Tad S Sonstegard, Curt P Van Tassell, Holly L Neibergs, John C McEwan, Rudiger Brauning, Luiz L Coutinho, Masroor E Babar, Gregory A Wilson, Matthew C McClure, Megan M Rolf, Jaewoo Kim, Robert D Schnabel, Jeremy F Taylor (2009). Resolving the evolution of extant and extinct ruminants with high-throughput phylogenomics. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 44, 18644-9
  • Erin N Gillenwaters, Christopher M Seabury, Janice S Elliott, James E Womack (2009). Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family. THE JOURNAL OF HEREDITY. 2, 241-5
  • T Raudsepp, A Gustafson-Seabury, K Durkin, M L Wagner, G Goh, C M Seabury, C Brinkmeyer-Langford, E-J Lee, R Agarwala, E Stallknecht-Rice, A A Schäffer, L C Skow, T Tozaki, H Yasue, M C T Penedo, L A Lyons, K A Khazanehdari, M M Binns, J N MacLeod, O Distl, G Guérin, T Leeb, J R Mickelson, B P Chowdhary (2008). A 4,103 marker integrated physical and comparative map of the horse genome. CYTOGENETIC AND GENOME RESEARCH. 1, 28-36
  • Brian W Brunelle, Justin J Greenlee, Christopher M Seabury, Charles E Brown, Eric M Nicholson (2008). Frequencies of polymorphisms associated with BSE resistance differ significantly between Bos taurus, Bos indicus, and composite cattle. BMC VETERINARY RESEARCH., 36
  • C M Seabury, J E Womack (2008). Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6. GENOMICS. 4, 235-45
  • Brian W Brunelle, Allison M O'Grady, Eric M Nicholson, Christopher M Seabury (2016). Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic Cattle. PLOS ONE. 5,
  • Daniel F Carlson, Cheryl A Lancto, Bin Zang, Eui-Soo Kim, Mark Walton, David Oldeschulte, Christopher Seabury, Tad S Sonstegard, Scott C Fahrenkrug (2016). Production of hornless dairy cattle from genome-edited cell lines. NATURE BIOTECHNOLOGY. 5, 479-81
  • Yvette A Halley, David L Oldeschulte, Eric K Bhattarai, Joshua Hill, Richard P Metz, Charles D Johnson, Steven M Presley, Rebekah E Ruzicka, Dale Rollins, Markus J Peterson, William J Murphy, Christopher M Seabury (2015). Northern Bobwhite (Colinus virginianus) Mitochondrial Population Genomics Reveals Structure, Divergence, and Evidence for Heteroplasmy. PLOS ONE. 12,
  • Polyana C Tizioto, JaeWoo Kim, Christopher M Seabury, Robert D Schnabel, Laurel J Gershwin, Alison L Van Eenennaam, Rachel Toaff-Rosenstein, Holly L Neibergs, , Jeremy F Taylor (2015). Immunological Response to Single Pathogen Challenge with Agents of the Bovine Respiratory Disease Complex: An RNA-Sequence Analysis of the Bronchial Lymph Node Transcriptome. PLOS ONE. 6,
  • Brian W Davis, Christopher M Seabury, Wesley A Brashear, Gang Li, Melody Roelke-Parker, William J Murphy (2015). Mechanisms Underlying Mammalian Hybrid Sterility in Two Feline Interspecies Models. MOLECULAR BIOLOGY AND EVOLUTION. 10, 2534-46
  • Holly L Neibergs, Christopher M Seabury, Andrzej J Wojtowicz, Zeping Wang, Erik Scraggs, Jennifer N Kiser, Mahesh Neupane, James E Womack, Alison Van Eenennaam, Gerald Robert Hagevoort, Terry W Lehenbauer, Sharif Aly, Jessica Davis, Jeremy F Taylor, (2015). Susceptibility loci revealed for bovine respiratory disease complex in pre-weaned holstein calves. BMC GENOMICS., 1164
  • Mahdi Saatchi, Jonathan E Beever, Jared E Decker, Dan B Faulkner, Harvey C Freetly, Stephanie L Hansen, Helen Yampara-Iquise, Kristen A Johnson, Stephen D Kachman, Monty S Kerley, JaeWoo Kim, Daniel D Loy, Elisa Marques, Holly L Neibergs, E John Pollak, Robert D Schnabel, Christopher M Seabury, Daniel W Shike, Warren M Snelling, Matthew L Spangler, Robert L Weaber, Dorian J Garrick, Jeremy F Taylor (2014). QTLs associated with dry matter intake, metabolic mid-test weight, growth and feed efficiency have little overlap across 4 beef cattle studies. BMC GENOMICS., 1004

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